The cleanest way to do your grounds is to install a buss bar and land all the grounds on the buss bar that way you only have one cable on each side of the shunt.
I get you wanting to go with 2/0 which is 195 Amps, and while I’m a fan of “overkill is underrated” that is over kill but, if you can get it in there without dramas its certainly not going to hurt anything except your wallet. Having piece of mind is priceless.
Your 100 amp fuse on the #4 is basically an over fuse of 5%, since your amp has its own 50 Amp fuse, you are only protecting the length of
#4, so with a 100 A fuse you are fused at 105% roughly.
Here is what I suggest you do with your current (see what I did there?) set up. Install the shunt, get your universal battery cable from the auto parts store to go from the battery to the shunt, and then attach your system grounds on the other side of the shunt being sure to put the largest cables on the bottom and the thinnest towards the top or nut part of the bolt.
Once the shunt is installed and you have installed the app on your phone, turn on each device separately to measure their draws. Then with all devices off start the engine and see how much it draws, the instantaneous amp draw should be recorded in the graphical page of the smart shunt.
By doing the two aforementioned steps you will KNOW exactly how much draw you will have on your battery and can then make educated and informed decisions about how you will proceed with your system design. Not measuring all of those loads / draws will just be a guess or an assumption.