For a big lake like that, I would think so, but it can be just the opposite for smaller lakes, depending on the topography underwater as well. On my lake, or Lake Winnebago, for that matter, it's fairly shallow, so certain winds will just make it hell to go out, even if it's just a 10mph day. There's not much land break on our lake, but an east wind seems to generate the worst conditions on our lake, even with another lake to the east, and connected to ours (so no land break at all above water). There's a shallow area dividing the two lakes, and it seems to be the reason an east wind isn't too kind to us, letting the wind skate over those shallows and hit us a bit harder.
Depending on the season, it can suck too. Constant or heavy south winds bring us tons of ice up on shore, to the point of damaging some boathouses that are set back 15+ feet from the shore. Thankfully, that hasn't happened for a few years, but we have to fortify our shoreline periodically to avoid erosion damage from the ice.