It's probably not as bad as you could imagine to make this trip from out west. We started in Battle Ground, WA and it took us 3.5 days to get there with a couple rest area sleep breaks and a couple motel stops. I drove the whole way myself and pushed hard but not too hard. I'd encourage other westerners to do it if you have the time. Also there is safety in numbers if some folks were at least taking the same route. Our round trip's gas bill was about $1500-$1600. And we avg about 9.5 mpg.
We (I) ran out of gas once in the middle of Wyoming (11 miles short of an open gas station) and had to wait about 2.5 hours for some $6 gallon gas to be delivered in the middle of the night. Good Sam roadside assistance and the WY state police helped arrange that.
One motel stop along the way was for a 2 hour nap and well needed/deserved showers for the crew. Lots of fuel stops helped force rest breaks on about 200 mile or 3 hour intervals. There was a little coffee and about 3 bottles of diet dew consumed.
Ft. Lauderdale was a welcome sight and there was no trouble getting to sleep at the BahiaMar.
I suggest packing a few things for the trip: Flashlights; headband and handheld, quality air compressor, gloves, tire pressure gauge, flares, rain gear, lug wrenches for truck and trailer, spare gas jugs (not empty-oooof), tire plug kit, spare fuses, and a jack.
On the trip home a trailer malfunction caused a blowout but otherwise was uneventful. We took our own sweet time going home with two full nights in motels and it was a 4.5 day drive home.
We had the privilege of a comfortable pickup to drive in and a bit of luck and a little preparation which made the trip quite doable. We are hoping to make it in '17 as well.