The core of scientific research and communication is peer review, which this obviously isn't subject to. Anyone can publish anything on Zenodo - I could print this thread to PDF and title it "Coalescion of marine experts' review of existing data related to COVID-19 and US Pandemic Response" and it would be published.
The point about this not being research is this: its not
research. She and her colleagues are simply musing about the ways in which this could be accomplished in a lab, whereas actual reviews of the sequence of the virus have clearly shown that effects of manipulation are not present within its genome. People making claims such as this would actually demonstrate the methods involved and the resulting sequence modifications that would yield an identical code absent the markers of manipulations.
In the time frame they specified they could have accomplished many of these tasks independently, if not as a whole, and offered a synthetically derived version of SARS-CoV-2 either in its entirety or in part. Peers would then review the methods and attempt to replicate. It's the underpinning of science. Moreover, you'll note the absolute dearth of references to the claims they make. One of the points key to the central thesis of why this could not be naturally occurring is the the ACE2 inhibitor is not sufficiently conserved between bats and humans, so therefore the spike protein could never have naturally occurred with a high enough affinity to the receptor binding domain for human infection, never mind the fact that this already occurred in our recent history, and has been demonstrated in other coronaviruses in the
bat population that emerged prior to SARS. She purports that much of this manipulation can be done with basic restriction enzyme digestion and recombination with EcoR1, shit that I did in high school nearly 20 years ago, and yet this would not be perceptible by the all of the peer-reviewed work that's been published to date? Even the language of the article is frankly laughable compared to the norms of research. I think I lost count of how many times I came across astonishingly, conveniently, and strikingly (and a littany of other adverbs), alongside the big underlined smoking gun.
Bias matters. Look at who wrote it, what they have to gain by it, who published it and what they have to gain by it, and you're left with a bucket of pseudoscience that puts some things in clear language that will serve only to distract and divide, while the meat of it in language that the vast majority of readers will have no fundamental (let alone technical) understanding of, and its primed for a misinformation campaign and soundbites to fly through social media - which not
astonishingly, has gone like wildfire.
Cute. I'm not an expert by any means, but I'd wager I have the education, training, and experience to understand more of that text than most folks here.