Coronavirus

[tabbibus]

@tabbibus have you seen this article?

https://www.washingtonpost.com/health/2020/04/24/strokes-coronavirus-young-patients/

Yes. I've known about this for some time. Wife was tested and negative. But who knows.

 

[Mainah]

Our youth is our future. Many a high school or college senior has had their right of passage stolen by this pandemic. The dinner conversation at my table this evening turned to those seniors that have impressed us and has motivated me to write letters to them amd their parents. One quite and very intelligent young leader and one boisterous intelligent young get it done type have impressed me over the last few years. They both have very bright futures and have been accepted to the same D1 school. They obviously don’t need a letter from me. Affirmation in these uncertain times may mean more than I know. I am going to write a letter to both them and their parents. The fact these kids two years ahead of my own have impressed me enough to come up in dinner conversation after over a month of isolation says something. The fact these two stood out from all those that I know after volunteering many hours and attending many events at the school says something. That something is what I want to relay to them and affirm their path through their manner and work ethic in these uncertain times.

I encourage everyone wether seen as a leader/mentor or not to consider sending a note to those young folks who have left an impression on you. Imagine being in that transitional age and wondering what the heck is the future going to be like right now. Imagine wondering is anything I have done or will do going to make a difference. These young folks are our future and living through a very trying time. We need for them not to lose hope but rather be the hope of our future.

Considering taking some of your time to encourage the leaders and doers of the future.

 

[Bruce]

Topic change....I'm struggling with the lack of recoveries... Most last around 2 weeks sick, which should mean we have several more having recuperated, just based on time since onset. How come this is not reflecting as less active cases. Very few cases should be older than 3 weeks. What gives?

This document is from a low quality source (The Sun) but it does a good job of conveying the progression as documented in medical journals.

I believe that the FDA standard for recovered is two weeks without symptoms. My state of Arkansas uses a much lower threshold.

 

[Beachbummer]

So, With that (Along my same thoughts) How come cases are going up if we had a relatively constant average of new cases over the last 22 days.

Those Entering the "Sick room" should match more or less those exiting the room at this point. The quantity of those in the room should be stable now.What am I missing?

From United States Coronavirus: 1,004,645 Cases and 56,495 Deaths - Worldometer



Thanks again!

 

[Julian]

So, With that (Along my same thoughts) How come cases are going up if we had a relatively constant average of new cases over the last 22 days.

Those Entering the "Sick room" should match more or less those exiting the room at this point. The quantity of those in the room should be stable now.What am I missing?

From United States Coronavirus: 1,004,645 Cases and 56,495 Deaths - Worldometer
View attachment 117152


Thanks again!

My guess....lots of patient records with no outcome documented. Deaths always get documented, but the positive test result with the person who goes home....probably never will. Which is why you can't look at the closed cases chart because it doesnt have enough "true" closed cases reflected in it.



We clearly aren't seeing a 29% CFR (case fatality rate)....just incomplete data.

 

[Dixie Highway]

Also consider the increase in testing. Here in IL, we went from 1,500 tests/day to over 16,000 tests/day in the past few weeks. I’d suspect most states are seeing the same increase in testing.

 

[Liveto99]

evms.edu/covidcare
This has some great info on the treatment right from the medical school.
Click download the latest you can either get the 11 page version for critical care or just a summary.

 

[Liveto99]

COVID-19 - Eastern Virginia Medical School (EVMS), Norfolk, Hampton Roads

www.evms.edu

I am trying to put the link for above but having a hell of a time.
OK this is the link for the post above.

 

[Dean P]

COVID-19 - Eastern Virginia Medical School (EVMS), Norfolk, Hampton Roads

www.evms.edu

I am trying to put the link for above but having a hell of a time.
OK this is the link for the post above.

Thank you for sharing. I like the cocktail summary.

 

[GTBRMC]

"...hailed by Dr. Anthony Fauci, the nation’s top infectious disease expert, as “highly significant.” "
“This will be the standard of care,” Fauci predicted, adding, “The FDA, literally as we speak, is working with Gilead to figure out mechanisms to make this easily available to those who need it.”
“It is the first truly high-powered randomized placebo-controlled trial,” Fauci said.
“The data shows that remdesivir has a clear cut significant positive effect in diminishing the time to recover. This is really quite important,” Fauci told reporters at the White House, likening it to a moment in 1986 “when we were struggling for drugs for HIV and we had nothing.”

Data on Gilead drug raises hopes in pandemic fight, Fauci calls it 'highly significant'

The top U.S. infectious disease official said Gilead Sciences Inc's experimental antiviral drug remdesivir will become the standard of care for COVID-19 after early clinical trial results on Wednesday showed it helped patients recover more quickly from the illness caused...

www.reuters.com

 

[Dixie Highway]

Looks like some doctors are making very interesting headway with this virus.

Doctor develops process for identifying extreme COVID-19 cases and how to treat them

Dr. Tom Yadegar, pulmonologist and medical director of the intensive care unit at Providence Cedars-Sinai Tarzana Medical Center, explains.

news.yahoo.com

If I’m not mistaken this is a similar tactic with other viral diseases? For some reason it seems like immunosuppressants are used for those?

 

[seanmclean]

For some reason it seems like immunosuppressants are used for those?

One of the key contributors to acute respiratory distress syndrome is an overstimulation of the immune system. I won't get into the details, but there's a tipping point involved where your immune cells essentially lose the ability to target the infection and begin 'overcrowding' and impairing normal cellular functions and even outright damage to healthy cells. Modulating the immune system to prevent getting to that inflection point is a useful strategy.

 

[OCMD]

Here is an interesting study which just came out 3 days ago - not subjected to peer review as of yet. It suggests the initial under reporting of cases has skewed the numbers. The study estimates that there were 8.7 million coronavirus infections in the U.S. between March 8 and March 28. And as of April 17, 10% of Americans have been infected — which is roughly 33 million Americans which is a helluvalot more than reported. I have drawn my own unscientific conclusions.

Using influenza surveillance networks to estimate state-specific case detection rates and forecast SARS-CoV-2 spread in the United States

Detection of SARS-CoV-2 infections to date has relied on RT-PCR testing. However, a failure to identify early cases imported to a country, bottlenecks in RT-PCR testing, and the existence of infections which are asymptomatic, sub-clinical, or with an alternative presentation than the standard...

www.medrxiv.org

 

[Bruce]

More info on remdesivir. Not a cure but potentially reducing the length of illness and saving lives. Similar to tamiflu reducing the length of flu if taken early. But nothing like amoxicillin killing strep in 24 hours.

The biggest challenge to treatment with remdesivir is likely to be getting test results back quickly enough to begin the drug early.

Data on Gilead's antiviral bring hope for first Covid-19 drug approval

Hours after Gilead announced that an NIH trial testing their antiviral drug remdesivir in Covid-19 patients had succeeded, NIAID director Anthony Fauci sat on a couch in the Oval Office and gave the world the top-line readout. The drug induced a 31% improvement on the primary endpoint of time to

endpts.com

 

[Ronnie]

I haven’t posted to this thread in weeks, it got and I helped make it political. Regardless of the politics involved , this recently hit home hard. My Wife’s cousin in IL just passed away as a result of contracting the Corona Virus. She was 36 years old, a mother of three and a Registered Nurse. She was admitted to the hospital she worked at on Friday (two days ago) she died this morning. We just got the news. Thankfully she didn’t die alone but only because her coworkers were there to comfort her. She last spoke to her family by face time before they intubated (put her on a ventilator). For those that don’t think staying at home, social distancing, testing, etc. is important, I know of three kids and a widower who would strongly disagree, politics and/or the economy are the last things on their minds.

 

[tabbibus]

I'm sorry to hear that. My condolences. Did she have appropriate PPE? A friend of mine who works in my same hospital also has the virus. This sucks

 

[Speedling]

I haven’t posted to this thread in weeks, it got and I helped make it political. Regardless of the politics involved , this recently hit home hard. My Wife’s cousin in IL just passed away as a result of contracting the Corona Virus. She was 36 years old, a mother of three and a Registered Nurse. She was admitted to the hospital she worked at on Friday (two days ago) she died this morning. We just got the news. Thankfully she didn’t die alone but only because her coworkers were there to comfort her. She last spoke to her family by face time before they intubated (put her on a ventilator). For those that don’t think staying at home, social distancing, testing, etc. is important, I know of three kids and a widower who would strongly disagree, politics and/or the economy are the last things on their minds.

Do you know of any underlying condition? Scary as my wife and I are 36/37 with 3 kids.
Very sorry for all the losses!
We pray for the world's health multiple times a day!

 

[Bruce]

@Ronnie, so sorry for your loss. This virus is terrible. Especially for medical workers.

 

[ripler]

WTF? Let the conspiracy theories start.

Coronavirus In Pittsburgh: Researcher Killed In Apparent Murder-Suicide Was Close To ‘Making Very Significant Findings’ Related To COVID-19, Pitt Says – CBS Pittsburgh

A researcher killed in an apparent murder-suicide was close to "making very significant findings" related to COVID-19, his department said.

pittsburgh.cbslocal.com

 

[Ronnie]

An update to my last post on the subject, I got some of the details wrong but the result is the same. This article puts a face to the name. She was just like many of my family and friends, a nurse by choice, training and experience. Thinking about how we as a society could have done more to protect her and other health care professionals BUT DIDN’T sickens me. By analogy we sent our first responders to the front line with rocks instead of guns, and in some cases we are still doing so. Sorry not trying to make this political.

Young mom, a nurse at Bolingbrook nursing home with soaring COVID-19 toll, is the latest to die

Krist Angielen Castro Guzman, mother of three young children, died at AMITA Health Adventist Medical Center in Bolingbrook, where, less than five months earlier, she gave birth.

chicago.suntimes.com